Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 20;75(2):266–276. doi: 10.1002/ana.24088

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of Child Neurology Society/American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

B-cell clusters participating in oligoclonal band (OCB) production undergo immune stimulation in the periphery. (A) Lineage tree (organic layout) and (B) alignment of representative immunoglobulin G (Ig) heavy chain variable region (IgG-VH) amino acid sequences from Patient MS-5 are shown. Germline node (black arrow), node comprised of cerebrospinal fluid (CSF) and peripheral blood (PB) mononuclear cell (PBMC) IgG-VH (green arrow), and PB-derived subcluster identified by OCB peptide searches (gray arrow) are indicated. In the alignment, matched OCB peptides are shaded in gray; IgG-VH is derived from the Ig heavy chain variable germline gene (IGHV)3–9 germline segment. Only representative IgG-VHs are shown. Organic layout was chosen over hierarchic layout because the latter generates very extensive horizontal images. For additional information, please refer to the legends of Figures 1 and 2.