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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Neurobiol Aging. 2013 Dec 19;35(6):1510.e7–1510.e18. doi: 10.1016/j.neurobiolaging.2013.12.007

Table 3.

Clathrin-mediated endocytosis signaling pathway genes that are significantly associated (pcorrected<0.00026) with AMD after correcting for the 192 tests of genes outside of the APOE region.

GENE SNP CHR BP MA MAFa OR P pcorrected
APOM rs3130617 6 31627523 C 22.6% 0.83 4.39E-13 4.39E-12
CSNK2B rs805262 6 31628733 T 46.3% 1.20 2.44E-11 2.69E-10
HGS rs8070488 17 79663931 C 25.5% 0.91 1.88E-05 7.52E-05
a

MAF= Minor allele frequency, based on 1000 Genomes EUR population.; pcorrected=The gene-level corrected significance based on the peak SNP adjusted for effective number of tests within a gene.