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Mitochondrial accumulation of targeted lipophilic cationic antioxidants. A, Structure of TPP (triphenylphosphonium). B, Conjugation to a lipophilic cation such as TPP specifically targets the attached bioactive moiety (X) into the mitochondrial matrix in a ΔΨm-dependent fashion. This strategy leads to a 100-500 fold accumulation of the bioactive compound within mitochondria. TPP, triphenylphosphonium.
