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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Bone Miner Res. 2014 Apr;29(4):866–877. doi: 10.1002/jbmr.2108

Fig 2. RelB−/− mice have a transient increase in bone formation.

Fig 2

(A) Histology and histomorphometric analysis of OBs (green arrows) and OB surface (OB.S/BS) in the tibiae of 4-wk-old RelB−/− mice and WT littermates (n=7/group). (B) Double calcein labeling (arrows) in trabeculae in proximal tibial diaphyses corresponding to ROI-2 in Fig. 1 and analysis of dynamic parameters of bone formation: single labeled surface (sLS/BS), double labeled surface (dLS/BS), mineralization surface (MS/BS), mineral apposition rate (MAR) and bone formation rate (BFR) in 4-wk-old RelB−/− and WT mice (n=8/group). (C) Analysis of dynamic parameters of bone formation listed in (B) and OB surface in proximal tibial diaphyses of 7–8-week-old RelB−/− and WT mice (n=5–6/group). (D) Serum osteocalcin (OCal) levels from 4–5- (n=9) and 8–9-week-old (n=8) male and female WT and RelB−/− mice tested by ELISA.