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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Drug Test Anal. 2013 Sep 20;6(6):542–551. doi: 10.1002/dta.1534

Table 1.

Chromatographic data of chiral illicit drugs and controlled substances separated on the LARIHC CF6-P and LARIHC CF7-DMP columns in the optimized conditions.

Drug Structure CSP Mobile Phase rt1/min rt2/min α Rs
(1) Lysergic acid diethylamide (6aR,9R/6aS,9S)-9,10-Didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide graphic file with name nihms-534871-t0001.jpg LARIHC CF6-P 90ACN/10MeOH/0.3AA/0.2TEA 59.1 67.5 1.15 2.5
(2) Stanozolol (1S,3aS,3bR,5aS,10aS,10bS,12aS/1 R,3aR,3bS,5aR,10aR10bR,12aR)- 5α,17β-17-Methyl-2'H-androst-2-eno[3,2-c]pyrazol- 17-ol graphic file with name nihms-534871-t0002.jpg LARIHC CF6-P 80HEP/20EtOH/0.1TFA 24.0 34.7 1.51 2.0
(3) Cathinone HCl (R/S)-2-Amino-1 -phenyl-1 -propanone hydrochloride graphic file with name nihms-534871-t0003.jpg LARIHC CF6-P 70HEP/30EtOH/0.1TFA 50.7 55.0 1.09 1.5
(4) (R/S)-3,4-Methylenedioxyphenyl-2-butanamine hydrochloride graphic file with name nihms-534871-t0004.jpg LARIHC CF6-P 60ACN/40MeOH/0.3AA/0.2TEA 9.9 10.5 1.08 1.5
(5) Phenylpropanolamine (1R,2S/1S,2R)-α-Hydroxy-β- aminopropylbenzene hydrochloride graphic file with name nihms-534871-t0005.jpg LARIHC CF6-P 60ACN/40MeOH/0.3AA/0.2TEA 13.8 15.0 1.08 1.5
(6) Methadone (R/S)-6-Dimethylamino-4,4- diphenyl-3 -heptanone graphic file with name nihms-534871-t0006.jpg LARIHC CF6-P 85ACN/15MeOH/0.3AA/0.2TEA 16.5 18.2 1.13 1.3
(7) MDA (R/S)-3,4- Methylenedioxyamphetamine graphic file with name nihms-534871-t0007.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 46.5 48.7 1.05 1.3
(8) Venlafaxine (R/S)- 1-[2-(dimethylamino)-1 -(4- methoxyphenyl)ethyl]cyclohexanol hydrochloride graphic file with name nihms-534871-t0008.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 9.6 9.9 1.05 1.0
(9) (R/S)-p-Methoxyamphetamine hydrochloride graphic file with name nihms-534871-t0009.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 45.6 47.7 1.02 0.8
(10) Aminorex (R/S)-4,5-Dihydro-5-phenyl-2- oxazolamine graphic file with name nihms-534871-t0010.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 13.8 14.1 1.03 0.6
(11) Amphetamine (R/S)-1-Phenyl-2- aminopropane graphic file with name nihms-534871-t0011.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 44.1 44.5 1.01 0.4
(12) Hydrocodone (5R,9R,13S,14R/6R,9S,13R14 S)-4,5-Epoxy-3 -methoxy-17- methylmorphinan-6-one graphic file with name nihms-534871-t0012.jpg LARIHC CF6-P 80ACN/20MeOH/0.3AA/0.2TEA 11.1 11.3 1.03 0.5
(13) (R/S)-Clenbuterol graphic file with name nihms-534871-t0013.jpg LARIHC CF7- DMP 80Hep/20EtOH/0.1TFA 12.9 14.8 1.19 2.0
(14) Temazepam (R/S)-7-Chloro-1,3-dihydro-3-hyd roxy-1 -methyl-5-phenyl-2H-1,4- benzodiazepine-2-one graphic file with name nihms-534871-t0014.jpg LARIHC CF7- DMP 80Hep/20EtOH/0.1TFA 13.5 14.6 1.10 1.8

*Marks a stereogenic center. For the possible enantiomeric configurations about these centers, refer to the description in the drug name column.