TABLE 2.

-Fold up-regulation in the transcript level of different cathepsins

Data were taken from Ref. 19. Genome-wide gene expression analysis was done using an Affymetrix chip, and -fold differences in the Npc1^−/− were calculated relative to Npc1^+/− mice.

Marker (transcript)	-Fold increase in Npc1−/− liver (67–71 days)	-Fold increase in Npc1−/− brain (81–84 days)
Cathepsin B	1.53	2.82
Cathepsin D	3.22	1.95
Cathepsin S	6.26	2.77