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Effect of PKM2 and its mutants on aerobic glycolysis. A, glucose uptake by H1299 cells stably expressing independent and co-expressed wild-type and mutant PKM2. The highest uptake of glucose was demonstrated by PKM2-H391Y co-transfected cells. B, lactate production followed same pattern with maximal production by PKM2-H391Y co-transfected H1299 cells. *, p < 0.05.
