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Alignment of amino acid sequence of the different IP3Rs from various species
To identify the relevant Cys thiol group in the O2⨪-induced [Ca2+]c signal, we aligned the amino acid sequences of the three different IP3Rs from the various species. Analysis of the sequences indicates that three of the 51 cysteines present in the rat IP3R3 isoform are not conserved in the chicken or in the other two rat IP3R isoforms.
