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Pu-27 induces chromosomal aberrations in U937 cells. U937 cells were treated with Pu-27 for 5 days and were subjected to karyotype analysis and telomere-specific FISH. A and B, cells treated with Pu-27 showed extensive DNA damage throughout the chromosome. C and D, cells left untreated (C) and cells treated with Pu-27 (D) showed numerous chromosomal end telomeric signals. The arrow indicates several of the abnormalities.
