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Pu-27-treated cellular sensitivity was independent of p53. HCT116 p53+/+, HCT116 p53+/−, and HCT116 p53−/− cells were treated with Pu27. These cells show resistance to Pu-27 irrespective of their p53 status (p = 0.30, 0.78, and 0.15 in p53+/+, p53+/−, and p53−/− cells, respectively, at 10 μm of Pu-27 treatment).
