FIGURE 2.

Localization of S-palmitoylated Cys within rabbit RyR1 (shown in red), as identified by acyl-RAC. Previously identified sites of physiological S-oxidation (S-Ox) (5) and S-nitrosylation (S-NO) (2) are indicated. Transmembrane domains, regions implicated in the interaction of RyR1 with the L-type Ca²⁺ channel Ca_V1.1 (dihydropyridine receptor, DHPR), FK506-binding protein 12 (FKB12), and calmodulin (CaM), leucine/isoleucine zipper (LIZ) motifs, and the SPRY1 domain, as well as hot spot regions implicated in malignant hypothermia/central core disease (MH, CCD), are delineated on the basis of the human RyR1 sequence (reviewed recently in Ref. 39).