Standard dosage	5 mg once daily; may increase to 10 mg once daily after 4-6 weeks; effective dosage range in clinical studies: 5-10 mg/day
Contraindications	No absolute contraindications
Main drug interactions	May increase serum concentration of succinylcholine, and caution is advised if these agents are used concurrently [35]
Main side effects	Insomnia and other sleep disorders (abnormal dreams, vivid dreams, nightmares), dose-related anorexia/weight loss, diarrhea, nausea, and/or vomiting; may cause bradycardia or heart block in some individuals, independent of their personal history of cardiac disease. Lower-weight patients (<55 kg) may experience more nausea, vomiting, and weight loss compared to higher-weight patients.
Special points	Considered to improve “cognitive symptoms” in Alzheimer's Disease, but not classified as a “disease-modifying” agent.
Cost-effectiveness	Expensive