Standard dosage	Begin 5 mg/day, and increase by 5 mg each week, to achieve target dose of 20 mg/day. Total daily doses >5 mg daily should be given in two divided doses.
Contraindications	No absolute contraindications, but caution is advised in patients with cardiovascular disease—clinical trial data suggests an increased incidence of cardiac failure, angina, bradycardia, and hypertension, compared with placebo. Also, use with caution in patients with severe hepatic impairment.
Main drug interactions	Monitor closely when prescribed with trimethoprim, sodium bicarbonate, or carbonic anhydrase inhibitors [35]
Main side effects	Generally well tolerated; may cause dizziness, confusion, headache, somnolence or fatigue, vomiting, weight loss, cough in some individuals.
Special points	Currently, the only “disease-modifying” pharmacologic agent for the treatment of Alzheimer's Disease.
Cost-effectiveness	Expensive