Table 2. Comparison of various modalities with gene expression in terms of mean AUC (computed over datasets/tasks where data from both modalities was available).
| Mean AUC | Comparison of mean AUC differences | ||||
|---|---|---|---|---|---|
| Modality | Number of datasets/tasks where this modality was measured | this modality | gene expression modality | p-value | p-value adjusted for multiple comp. |
| Clinical | 47 | 0.686 | <0.788 | <10-5 | <10−5 |
| Protein expression | 27 | 0.725 | <0.742 | 0.1910 | 0.2183 |
| Somatic Mutations | 16 | 0.704 | <0.777 | 0.0023 | 0.0046 |
| DNA Methylation | 27 | 0.730 | <0.742 | 0.1290 | 0.1720 |
| miRNA Expression | 14 | 0.730 | <0.742 | 0.2585 | 0.2585 |
| Copy Number | 3 | 0.783 | <0.929 | <10−5 | <10−5 |
| Tumor Imaging | 1 | 0.947 | <0.979 | 0.0502* | 0.0803 |
| GWAS | 16 | 0.708 | <0.826 | <10−5 | <10−5 |
*Since there is only one dataset for tumor imaging, significance in difference between AUC was not assessed by permutation testing, but instead was assessed by the method of Delong43.