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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Clin Cancer Res. 2014 Jan 31;20(6):1610–1622. doi: 10.1158/1078-0432.CCR-13-2589

Figure 5. Inflammation-related Signaling Networks Differentially Activated in Cells Associated with Pre-initiated Lesions.

Figure 5

(A – R) Representative images of cJUN (A – I) and STAT3 Y705 (J – R) phosphorylation within hyperplasias, adenomas, or non-involved K-rasLA1 lung seventy days post-irradiation with an acute or fractionated dose of 1.0 Gy 56Fe- particles and age-matched unirradiated controls.

(S – T) Quantification of p-cJUN and p-STAT3 Y705 IHC analysis represented in (A – I) and (J – R), respectively (5 – 7 animals per group region; Non-involved: N = 5 fields per animal; hyperplasias: N = 11 – 13 per protein analyzed; adenomas: N = 19 – 26; Black outlines = Control; Red outlines = Acute; Blue outlines = Fractionated).

For non-involved regions, scale bars denote 100 μm; For initiated lesions, scale bars denote 50 μm; Graphs indicate median and quartiles (95% CI); IHC differences determined by two-way ANOVA with Tukey correction; *p < 0.05; **p < 0.01; **p < 0.001.