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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Neuroscience. 2013 Jul 30;252:489–500. doi: 10.1016/j.neuroscience.2013.07.052

Figure 6. Attenuation of blood brain barrier disruption in the ICH brain by pharmacological hypothermia.

Figure 6

Blood brain barrier was evaluated as the expression of occludin in fresh frozen slices 48 hrs after ICH and 24 hrs after HPI-201 treatment. A - C. Immunostaining images showing occludin expression (red) in the contralateral (A), ipsilateral sides saline control (B) and ipsilateral side treated with HPI-201 (C). Blue color is collagen IV. D. Quantified data of occludin expression shows partial recovery of occludin in the hypothermia-treated group. N=4 animals in each group, *. p<0.05 vs. contralateral side.