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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Neuroscience. 2013 Jul 30;252:489–500. doi: 10.1016/j.neuroscience.2013.07.052

Figure 7. Functional recovery after hemorrhagic stroke.

Figure 7

The behavioral test was performed at different days in ICH control mice and ICH mice treated with HPI-201 with 1 hr or 24 hr delay. An 18-grade modified NSS test was used to evaluate functional damage and recovery of experimental animals. Both score distribution plus the median (a thin bar located among the scattered data) and calculated mean and SEM (bar graph) are shown in the figure. All data were verified for normal Gaussian distribution before statistical analysis. The Kruskal-Wallis test and one-way ANOVA test were used for comparisons of the three experimental groups, and both methods showed a significant effect of reducing the functional deficits 2 days after ICH in mice received 1-hr delayed HPI-201 treatment. The effect of 24 hr-delayed HPI-201 treatment was not statistically significant when the NSS scores were compared with ICH controls. On the other hand, there was no statistical difference between the NSS scores of 24 hr and 1-hr delayed HPI-201 treatment. The same animals showed trends of improved behavioral recovery at 7 and 14 days after ICH, but statistical analyses showed no significant difference. *. p<0.05 vs. ICH control, n=9, 12, and 9 for the three group, respectively.