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Binding of HO-1 with various proteins. HO-1 can bind to itself, HO-2, and cytochrome c P450 reductase in the cytoplasm; whereas in the nucleus, it binds to various DNA repair proteins and also binds to transcription factors such as STAT3 and perhaps Nrf2. It can also bind to caveolin-1. STAT3, signal transducer and activator of transcription-3.
