FIG. 10.

Simplified diagram of Nrf2 participation in the processes of neovascularization and the effects of its deficiency. Nrf2 regulating proangiogenic genes, taking part in the functioning of endothelial cells and BM-derived PACs, and regulating the expression of cytoprotective genes may be an important mediator of neovascularization. However, in the absence of Nrf2 in vivo, following ischemia, angiogenesis associated with oxidative stress and inflammatory response could occur, despite an impaired function and mobilization of PACs. BM, bone marrow.