Table 6.
Association of Haplotype Diversity with OS in All Patients
| Haplotype* | Frequency | MST | HR (95% CI)‡ | P |
|---|---|---|---|---|
| GCK | ||||
| GGCCGCA | 0.2337 | 18.4 | 1.0 | |
| GGTCGCA | 0.1248 | 16.5 | 0.96 (0.79–1.18) | .73 |
| GGCTATC | 0.1218 | 16.2 | 1.21 (0.98–1.48) | .078 |
| GGCCACC | 0.098 | 18.7 | 0.93 (0.74–1.17) | .52 |
| AACCACC | 0.0925 | 17.6 | 0.90 (0.72–1.14) | .38 |
| GACCACC | 0.0572 | 17.9 | 1.22 (0.91–1.63) | .18 |
| Others† | 0.272 | 17.3 | 1.05 (0.88–1.25) | .57 |
| GFPT1 | ||||
| TTTG | 0.4165 | 17.6 | 1.0 | |
| TTGA | 0.2162 | 17.6 | 0.97 (0.82–1.13) | .66 |
| TCTG | 0.1468 | 16.0 | 1.16 (0.97–1.38) | .10 |
| CTGA | 0.1288 | 18.1 | 0.93 (0.76–1.13) | .46 |
| TTGG | 0.0358 | 15.3 | 1.20 (0.87–1.66) | .26 |
| Others† | 0.0559 | 18.2 | 0.96 (0.71–1.29) | .77 |
| GPI | ||||
| TCA | 0.808 | 16.6 | 1.0 | |
| TGA | 0.1154 | 16.9 | 0.87 (0.72–1.06) | .17 |
| CGG | 0.0555 | 29.8 | 0.66 (0.49–0.88) | .004 |
| CCG | 0.01 | 13.0 | 2.17 (1.16–4.06) | .01 |
| Others† | 0.0111 | 37.1 | 0.64 (0.33–1.25) | .19 |
| HK2 | ||||
| GCCGTGG | 0.0817 | 16.2 | 1.0 | |
| ATTGTGG | 0.0553 | 16.3 | 1.01 (0.76–1.34) | .93 |
| GCTATGG | 0.0391 | 25.8 | 0.62 (0.44–0.88) | .007 |
| ACCATGG | 0.0353 | 23.9 | 0.85 (0.62–1.17) | .33 |
| ATTACAT | 0.0308 | 13.6 | 1.42 (1.02–1.96) | .03 |
| ACTATGG | 0.0299 | 27.5 | 0.95 (0.62–1.47) | .83 |
| GCCGCAT | 0.028 | 11.7 | 1.46 (0.99–2.14) | .055 |
| ACTGTGG | 0.0247 | 24.6 | 0.92 (0.58–1.44) | .71 |
| GCCATGG | 0.0219 | 21.5 | 1.12 (0.64–1.95) | .70 |
| ATTGCAT | 0.0214 | 14.2 | 1.47 (0.98–2.21) | .06 |
| Others† | 0.6319 | 17.3 | 1.05 (0.87–1.27) | .60 |
| OGT | ||||
| GA | 0.5394 | 17.8 | 1.0 | |
| GG | 0.3098 | 15.4 | 1.09 (0.95–1.24) | .23 |
| AG | 0.1201 | 16.3 | 1.12 (0.92–1.35) | .26 |
| AA | 0.0307 | 18.2 | 0.81 (0.54–1.22) | .31 |
MST, median survival time (months); HR: hazard ratio; CI, confidence interval.
Haplotypes of GCK −515G>A, IVS1-11823G>A, IVS1+6037T>C, IVS1+9652C>T, IVS1+11382G>A, IVS3-1489C>T, IVS6+87A>C; GFPT1 IVS12-1764C>T, IVS14-3094T>C, Ex19-115G>T, 4058A>G; GPI IVS6-378T>C, IVS9+2363C>G, G163G; HK2 IVS1-6165G>A, IVS1+7072C>T, IVS2+3581C>T, Ex1+318A>G, Ex15+41C>T (N692N), Ex16-78A>G (L766L), Ex18+407T>G; and OGT IVS8-72G>A and IVS18-424A>G. Three HK2 genotypes were not included in the haplotype analysis because the major allele was present in each of the haplotype group presented.
HR values were from multivariable Cox regression models including sex, race, clinical stage, tumor resection, CA19-9, performance status and biochemical index.
Others include all the haplotypes with an extremely low frequency.