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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Nature. 2013 Dec 15;505(7482):218–222. doi: 10.1038/nature12799

Figure 1. PDIM mediated evasion of MyD88 dependent macrophage recruitment.

Figure 1

a, Schematic of a 2dpf zebrafish showing the hindbrain ventricle (HBV) injection site outlined with dashed white line. Scale bar = 500 μm. b-c, Mean macrophage recruitment at 3 HPI into the HBV of wild-type or MyD88-morphant (MO) fish following infection with 150 S. aureus, 200 P. aeruginosa (b), 80 M. marinum or 85 M. smegmatis (c). Representative of three separate experiments. d, Mean bacterial burdens at 3 DPI following HBV infection of wild-type fish with 80 wild-type, ΔmmpL7, or Δerp M. marinum. Representative of three separate experiments. e, Mean macrophage recruitment at 3 HPI into the HBV of wild-type or MyD88 MO fish following infection with ΔmmpL7 or Δerp M. marinum. Representative of four separate experiments. f, Mean bacterial burdens of wild-type or MyD88 MO fish at 3 DPI following HBV infection with wild-type or ΔmmpL7 M. marinum. Representative of three separate experiments. Significance testing for all panels done using one-way ANOVA, with Bonferroni's post-test for comparisons shown, *P < 0.05; ***P < 0.001.