Table 1.

Extrahepatic autoimmune-related signs and symptoms in patients with chronic hepatitis C virus infection

Clinical manifestations	Arthralgia/myalgia
	Arthritis
	Sicca syndrome
	Purpura
	Lymphadenopathy
	Pulmonary fibrosis
	Raynaud’s phenomenon
	Fibromyalgia
	Thyroid dysfunction
Biological manifestations	Cryoglobulinemia
	Autoimmune hemolytic anemia
	Thrombocytopenia
	Hypocomplementemia
Autoantibodies	RF
	ANA
	Anti-SM and Anti-LKM1 antibody
	Anti-thyroglobulin and Anti-TPO antibody
	Anti-CL antibody

RF: Rheumatoid factor; ANA: Anti-nuclear antibody; Anti-SM: Anti-smooth muscle; Anti-LKM1: Anti-liver kidney microsomal type 1; Anti-TPO: Anti-thyroid peroxidase; Anti-CL: Anti-cardiolipin.