Table 2.
Selected models including indirect markers of liver fibrosis
| Score (original reference) | Variables | Performance in HCV patients1 |
|||||
| Significant fibrosis (≥ F2) |
Cirrhosis (≥ F4) |
||||||
| Median AUROC | Median sensitivity2 | Median specificity2 | Median AUROC | Median sensitivity2 | Median specificity2 | ||
| APRI[24] | AST and platelet count | 0.77 | 81% | 95% | 0.84 | 77% | 94% |
| FIB-43[41] | Age, AST, ALT and platelet count | 0.74 | 64% | 79% | 0.87 | 90% | 92% |
| Forns index[48] | Age, platelet count, cholesterol levels, and GGT | 0.76 | 88% | 94% | 0.87 | 98% | 91% |
| Fibro index[50] | Platelet count, AST, and gamma globulin | 0.76 | 94% | 97% | 0.86 | 70% | 91% |
1
Based on reference number 49;
2
Sensitivity values are presented for the lower cutoff and specificity for the upper cutoff (when multiple cutoffs are presented); 3Model originally proposed for HIV/HCV co-infected patients. HCV: Hepatitis C virus; AUROC: Area under the receiver operating characteristic curve; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; HIV: Human immunodeficiency virus.