Table 3.
Most studied models combining direct and indirect biomarkers for the diagnosis of liver fibrosis in chronic hepatitis C
| Score (original reference) | Variables | Performance in HCV patients1 |
|||||
| Significant fibrosis (≥ F2) |
Cirrhosis (≥ F4) |
||||||
| Median AUROC | Median sensitivity2 | Median specificity2 | Median AUROC | Median sensitivity2 | Median specificity2 | ||
| FibroTest[53] | Age, sex, serum haptoglobin, α2-macroglobulin, apolipoprotein A1, GGT, and total bilirubin | 0.79 | 92% | 96% | 0.86 | 85% | 81% |
| ELF[56] | Age, TIMP-1, PIIINP and hyaluronic acid | 0.81 | 85% | 70% | 0.88 | - | - |
| Fibrometer[61] | Platelet count, prothrombin index, AST, α2-macroglobulin, hyaluronic acid, blood urea nitrogen and age | 0.82 | 69% | 81% | 0.91 | - | - |
| FIBROspect II[63] | TIMP-1, α2-macroglobulin and hyaluronic acid | 0.86 | 80% | 70% | - | - | - |
| Hepascore[66] | Age, sex, α2-macroglobulin, hyaluronic acid, GGT and total bilirubin | 0.79 | 66% | 79% | 0.89 | 72% | 86% |
1
Based on reference number 49;
2
Sensitivity values are presented for the lower cutoff and specificity for the upper cutoff (when multiple cutoffs are presented). ELF: Enhanced liver fibrosis; HCV: Hepatitis C virus; AUROC: Area under the receiver operating characteristic curve; GGT: Gamma-glutamyltransferase; TIMP: Tissue inhibitor of matrix metalloproteinases; PIIINP: Procollagen type III amino-terminal peptide; AST: Aspartate aminotransferase.