Table 4.

Medical family history of selected non-malignant diseases.

	Case number (n = 1842)	Control number (n = 1986)	Adjusted ORa	(95%CI)	P-value (test for trend)
Allergic diseasesb	1436	1610	0.86	0.73, 1.00
Food and drug allergies	1068	1231	0.83	0.73, 0.95
Asthma	542	586	0.99	0.86, 1.13
Hay fever	754	863	0.89	0.78, 1.01
Hives	473	522	0.98	0.85, 1.14
Eczema	296	354	0.87	0.73, 1.04
Number of relatives with allergic diseases
0	1351	1425	1.00		P = 0.14
1	338	263	0.86	0.70, 1.05
2	306	342	0.83	0.67, 1.03
3	237	273	0.79	0.63, 1.00
4	196	201	0.89	0.69, 1.14
5+	359	431	0.75	0.61, 0.92
Parents only	967	1020	0.97	0.83, 1.12
Grandparents only	727	769	1.09	0.92,1.30
Maternal side only	937	1097	0.86	0.76, 0.98
Paternal side only	870	844	1.23	1.07, 1.41
Female relatives only	1007	1100	1.00	0.88, 1.14
Male relatives only	869	915	1.06	0.93, 1.21
Autoimmune diseases	491	461	0.92	0.80, 1.06
Multiple sclerosis	20	27	0.81	0.45, 1.46
Rheumatoid arthritis	220	286	0.79	0.65, 0.96
Psoriasis	143	146	1.07	0.84, 1.36
Ulcerative colitis	81	81	1.07	0.78, 1.47
Celiac disease	6	7	1.06	0.35, 3.20
Lupus	24	19	1.40	0.76, 2.55
Sarcoidosis	5	7	0.80	0.25, 2.54
Ankylosing spondylitis	4	4	1.17	0.29, 4.82
Diabetes	91	81	1.20	0.88, 1.64
Number of relatives with autoimmune diseases
0	1351	1425	1.00		P = 0.32
1	351	421	0.88	0.74, 1.03
2	102	100	1.08	0.81, 1.44
3	22	29	0.79	0.45, 1.40
4+	16	11	1.47	0.67, 3.23
Parents only	120	161	0.79	0.61, 1.04
Grandparents only	326	328	1.10	0.90, 1.35
Maternal side only	301	340	0.94	0.80, 1.12
Paternal side only	232	266	0.93	0.77, 1.13
Female relatives only	335	382	0.93	0.79, 1.10
Male relatives only	223	242	0.98	0.81, 1.19
Birth defects	105	127	0.87	0.66, 1.14
Number of relatives with birth defects
0	1737	1859	1.00		P = 0.59
1	93	112	0.87	0.65, 1.16
2+	12	15	0.85	0.40, 1.82
Parents only	79	88	0.96	0.69, 1.34
Grandparents only	27	43	0.63	0.37, 1.05
Maternal side only	58	80	0.77	0.54, 1.09
Paternal side only	54	50	1.17	0.78, 1.74
Female relatives only	54	75	0.76	0.53, 1.08
Male relatives only	61	59	1.11	0.76, 1.61
Immunodeficiency and recurrent infections	268	297	0.97	0.81, 1.17
Number of relatives with immunodeficiency and recurrent infections
0	1574	1689	1.00		P = 0.36
1	203	243	0.90	0.73, 1.10
2	54	45	1.29	0.86, 1.92
3+	11	9	1.34	0.55, 3.28
Parents only	8	9	0.98	0.35, 2.73
Grandparents only	7	8	0.75	0.26, 2.18
Maternal side only	203	228	0.99	0.97, 1.00
Paternal side only	82	82	1.09	0.79, 1.51
Female relatives only	204	237	0.92	0.75, 1.12
Male relatives only	95	86	1.23	0.90, 1.68
Thyroid	231	236	1.16	0.67, 2.00
Hyperthyroidism or Grave's disease	92	90	1.12	0.83, 1.51
Thyroiditis or Hashimoto's	27	25	1.16	0.67, 2.00
Hypothyroidism	130	151	0.95	0.74, 1.22
Number of relatives with thyroid disease
0	1611	1750	1.00		P = 0.41
1	197	193	1.16	0.92, 1.41
2+	34	43	0.87	0.55, 1.37
Parents only	69	65	1.17	0.82, 1.67
Grandparents only	153	152	1.10	0.85, 1.44
Maternal side only	169	177	1.05	0.84, 1.31
Paternal side only	65	67	1.08	0.76, 1.53
Female relatives only	201	216	1.03	0.84, 1.26
Male relatives only	30	26	1.22	0.72, 2.07

^aOdds ratios were derived from conditional logistical regression analysis and are adjusted for maternal age, birth weight and total number of relatives.

^bAll analyses including allergic diseases have been adjusted for personal history of allergies. In addition to the variables listed above.