Figure 1.

Multiple sequence alignment of the murine, human, equine and canine TLR4 sequences [18, 30]. The TLR4 protein sequence identification number (gi of NCBI records) is given in addition to the species letter (h, c, m or e). A comment line above the sequence blocks refers to residues discussed in the text (underlined, bold face). The last line of a MSA block labels the homology relationship (full identity “*”; high similarity “:”; low similarity “.” while blank space marks missing homology). The residue numbers follow the equine length for being without gaps.