Table 1.

Relevant data on SLC13A family members.

Gene	Main expression	Substrates	Physiological Relevance
Slc13a1	Renal proximal tubulus	Sulfate, Thiosulfate	sulfate homeostasis
	Intestinal epithelial cells	Selenite
		Na+
Slc13a2	Metabolically relevant epithelia	Succinate	Tri/Dicarboxylate homeostasis
	Renal proximal tubulus	α-Ketoglutarate
	Intestinal epithelial cells	Citrate
Slc13a3	Brain	Succinate	Tri/Dicarboxylate homeostasis cellular senescence (?),
	Kidney	α-Ketoglutarate	Axenfeld-Rieger Syndrome type I
	Placenta	Citrate
	Liver Pancreas
	Eye optic nerve
Slc13a4	Placenta	Sulfate	Unknown
	Testis
	Brain Heart
	Thymus
	Liver
	Tonsils
Slc13a5	Liver	Citrate	Tri/Dicarboxylate homeostasis metabolic processes such as fatty acid synthesis, gluconeogenesis
	Testis	Succinate
	Brain	Malate Fumarate