Table 1.
Gene | Main expression | Substrates | Physiological Relevance |
---|---|---|---|
Slc13a1 | Renal proximal tubulus | Sulfate, Thiosulfate | sulfate homeostasis |
Intestinal epithelial cells | Selenite | ||
Na+ | |||
Slc13a2 | Metabolically relevant epithelia | Succinate | Tri/Dicarboxylate homeostasis |
Renal proximal tubulus | α-Ketoglutarate | ||
Intestinal epithelial cells | Citrate | ||
Slc13a3 | Brain | Succinate | Tri/Dicarboxylate homeostasis cellular senescence (?), |
Kidney | α-Ketoglutarate | Axenfeld-Rieger Syndrome type I | |
Placenta | Citrate | ||
Liver Pancreas | |||
Eye optic nerve | |||
Slc13a4 | Placenta | Sulfate | Unknown |
Testis | |||
Brain Heart | |||
Thymus | |||
Liver | |||
Tonsils | |||
Slc13a5 | Liver | Citrate | Tri/Dicarboxylate homeostasis metabolic processes such as fatty acid synthesis, gluconeogenesis |
Testis | Succinate | ||
Brain | Malate Fumarate |