Figure 2.

Metabolic events in XIT and potential targets of LC-MS-based metabolomics. Biotransformation of xenobiotics and xenobiotic-induced metabolic changes occur simultaneously during the initiation and progression of XIT. LC-MS-based metabolomics is not only able to identify the metabolites generated or affected by these events (exploratory investigation), but also capable of revealing the biochemical mechanisms underlying these events when combined with other experimental models and biochemical analyses (hypothesis-driven investigation).