Figure 1.

Simplistic model of a cellulosome that includes only one anchoring scaffoldin. The scaffolding protein (blue) binds the enzymatic components through cohesin-dockerin interactions, enhances the cellulosome affinity for cellulose through the CBMs, and anchors the cellulosome complex to the cell surface through either non-covalent (by means of multiple S-layer homology domains) or covalent (mediated by sortases) bonds. Apart from the catalytic domains, cellulosomal enzymes include dockerin modules and, possibly, additional domains (e.g. CBM, SLH) (modified from [60]).