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. 2012 Nov 17;3:e201210010. doi: 10.5936/csbj.201210010

Figure 1.

Figure 1

6-Deoxyerythronolide B synthase (DEBS). DEBS contains a module for each of the 6 cycles of chain extension. Each module catalyses incorporation of a (2S)-methylmalonyl CoA derived propionate unit into an acyl chain, to form a 2-methylbranched 3-ketoacyl intermediate. The level of processing of the β-ketone group is determined by the reduction domains. Each module also determines the final stereochemistry of methyl- and hydroxyl-bearing centres.