Table 3.
Univariate and multivariate logistic regression analysis for clonal evolution
| Factor | Univariate logistic regression analysis: evolution | Multivariate logistic regression analysis: evolution | ||||
|---|---|---|---|---|---|---|
| Coefficient | SD | P value | Coefficient | SD | P value | |
| Age | −0.0225 | 0.0211 | .2873 | −0.0122 | 0.0279 | .6603 |
| Male gender | 2.0031 | 1.1212 | .0740 | 2.3316 | 1.7582 | .1848 |
| ANC | −0.1307 | 0.7649 | .8643 | 0.7459 | 0.9201 | .4176 |
| ARC | −0.0188 | 0.0193 | .3301 | −0.0229 | 0.0256 | .3697 |
| Relapsed refractory | 1.5755 | 0.8373 | .0599 | 2.2455 | 1.9191 | .2420 |
| Prior IST treatments | ||||||
| 1 IST course | — | — | — | — | — | — |
| 2 IST courses | 15.0620 | 906.943 | .9868 | 13.0273 | 866.145 | .9880 |
| 3 IST courses | 15.5852 | 906.943 | .9863 | 14.3640 | 866.149 | .9868 |
| 4 IST courses | 15.8729 | 906.944 | .9860 | 14.7658 | 866.155 | .9864 |
| Years since last IST | −0.0078 | 0.0241 | .7463 | −0.3367 | 0.4787 | .4818 |
| Years since diagnosis | 0.0866 | 0.1059 | .4133 | −0.0337 | 0.3942 | .9318 |
| PNH clone | −0.8109 | 0.8851 | .3595 | −2.3858 | 1.9912 | .2308 |
—, baseline value; ARC, absolute reticulocyte count; SD, standard deviation.