Figure 4.

Murine erythroid lncRNAs are largely conserved between different mouse strains. (A) Cross-expression of coding and lncRNA genes in splenic erythroblasts of 8 different mouse strains. Note that lncRNA expression is generally conserved between strains, although at a slightly lower level than coding genes. (B) Similar analysis as in panel A, with lowest expression quartile of lncRNAs excluded, shows more than 95% conserved lncRNA expression between most strains. (C) Comparisons of coding and lncRNA gene expression levels in 2 representative pairs of mouse strains. Note that the expression levels of both lncRNA and coding genes are conserved (2-tailed Spearman’s R >0.95 for coding mRNAs, >0.89 for low-stringency lncRNAs, and >0.80 for high-stringency lncRNAs).