Table 1.
Association of Iddm14 genotype and diabetes susceptibility in (LEW.1WR1 × WF.ART2a/a)F2 rats
Iddm14 genotype | Number diabetic (%) | Number nondiabetic (%) | Totals |
---|---|---|---|
L/L | 10 (50) | 10 (50) | 20 |
L/W | 19 (43) | 25 (57) | 44 |
W/W | 0 (0) | 11 (100) | 11 |
Totals | 29 (39) | 46 (61) | 75 |
L = LEW.1WR1-origin allele of Iddm14; W = WF.ART2a/a-origin allele
(LEW.1WR1 × WF)F2 rats were bred, treated with poly I:C to induce diabetes, and genotyped to determine the origin of Iddm14 alleles as described in Methods. All diabetic animals were found to have inherited at least one LEW.1WR1-origin allele of Iddm14 (p <0.01)