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. 2014;54(3):296–303. doi: 10.1093/ilar/ilt047

Figure 3.

Figure 3

Decreased C-fiber conduction velocity in SIV-infected macaques strongly correlated with CD68 expression in the lumbar DRG. (A) Mean sural nerve C-fiber CV was significantly slower in SIV-animals evaluated at twelve weeks p.i. when compared to uninfected controls or SIV-infected animals evaluated at six or eight weeks p.i. (P = 0.003, analysis of variance). (B) Comparing the mean C-fiber CV of SIV-infected animals to corresponding levels of CD68 immunostaining in the lumbar DRG demonstrated a strong inverse correlation between slowing of CV in C-fibers and macrophage activation and infiltration in the DRG (P = 0.006, r = -0.97, Pearson correlation coefficient). Reprinted with permission from Laast et al. (2011).