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. Author manuscript; available in PMC: 2014 Mar 21.
Published in final edited form as: J Med Chem. 2013 Nov 20;56(23):9693–9700. doi: 10.1021/jm4013888

Table 4.

SAR Study of R3

graphic file with name nihms560929u4.jpg
Compound NHR3 IC50 (μM)a
Mer Axl Tyro3
34 graphic file with name nihms560929t37.jpg 2.4 16.6 >30
35 graphic file with name nihms560929t38.jpg 0.15 1.2 >30
36 graphic file with name nihms560929t39.jpg 0.037 0.78 16.2
37 graphic file with name nihms560929t40.jpg 0.011 0.61 1.2
38 graphic file with name nihms560929t41.jpg 0.027 1.1 21.9
39 graphic file with name nihms560929t42.jpg 0.0073 0.30 0.94
40 graphic file with name nihms560929t43.jpg 0.086 5.7 5.1
41 graphic file with name nihms560929t44.jpg 0.059 4.3 6.7
42 graphic file with name nihms560929t45.jpg 0.024 1.9 1.7
43 graphic file with name nihms560929t46.jpg 0.047 9.0 4.3
44 graphic file with name nihms560929t47.jpg 0.18 7.4 2.3
45 graphic file with name nihms560929t48.jpg 0.12 >30 >30
46 graphic file with name nihms560929t49.jpg >30 >30 >30
47 graphic file with name nihms560929t50.jpg >30 >30 >30
a

Values are the mean of two or more independent assays.