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. Author manuscript; available in PMC: 2014 Mar 21.
Published in final edited form as: J Med Chem. 2013 Nov 20;56(23):9693–9700. doi: 10.1021/jm4013888

Table 5.

PK profile of 23

Routea T1/2 (h) Tmax (h) Cmax (ng/mL) AUClast (h*ng/mL) Cl_obs (mL/min/kg) Vss (L/kg) %F
IV 0.80 - 2609 527 94.5 1.65 -
PO - 0.30 90.0 71.7 - - 14
a

a dose of 3 mg/kg for both routes.