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. Author manuscript; available in PMC: 2014 Mar 21.
Published in final edited form as: Stem Cells. 2009 Mar;27(3):533–542. doi: 10.1634/stemcells.2008-0596

Figure 6.

Figure 6

Data mining reveals small molecule targets that decrease OCT4-positive human embryonic stem cells (hESCs). (A): Scatter plot from the combined libraries (Biomol and Prestwick) showing targets from the HA-treated hESCs. (B): Scatter plot from the combined libraries (Biomol and Prestwick) showing targets from the shRNA-hESCs. (A, B): Arrows represent potential clusters of targets that decrease OCT4-positive hESCs. (C, D): Treatment of HSF1 hESCs with 10 μM simvastatin results in decreased SSEA4-positive hESCs. Comparison of wild-type (C) and shRNA (D) treated with HA and/or simvastatin revealed increased Annexin-positive (cell death) hESCs upon simvastatin treatment, whereas treatment with HA or shRNA-hESC lines had reduced Annexin-positive cells. Abbreviations: HA, HA-1077; shRNA, short hairpin RNA; SSEA4, stage-specific embryonic antigen 4.