Table 3. Overall and subgroup results of the association between MTHFR A1298C polymorphism and NSCL/P.

Study(n)	T vs. C		TT vs. CC		CT vs. CC		CT/TT vs. CC		TT vs. CC/CT
	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)	P
Overall
Children(n = 6)	1.03(0.79–1.35)	0.819	1.08(0.78–1.48)	0.652	1.01(0.68–1.48)	0.982	1.03(0.71–1.48)	0.881	1.09(0.80–1.48)	0.578
Mothers(n = 3)	0.94(0.73–1.20)	0.593	0.78(0.40–1.50)	0.452	0.98(0.71–1.35)	0.905	0.95(0.70–1.30)	0.751	0.79(0.41–1.50)	0.467
Eastern Asia
Children(n = 3)	1.05(0.61–1.82)	0.855	0.97(0.47–1.99)	0.930	1.16(0.44–3.06)	0.767	1.13(0.49–2.61)	0.768	0.96(0.48–1.93)	0.907
Mothers(n = 1)										0.224
Western/Central Asia
Children(n = 3)	1.04(0.73–1.49)	0.819	1.23(0.53–2.85)	0.626	0.94(0.76–1.16)	0.551	0.98 (0.66–1.44)	0.901	1.23(0.60–2.53)	0.568
Mothers(n = 2)	0.83(0.62–1.12)	0.218	0.81(0.20–3.27)	0.767	0.81(0.54–1.20)	0.283	0.79(0.54–1.15)	0.218	0.88(0.24–3.17)	0.839