Table 3. Enriched immunity- and biomineralisation-related GO terms (default topGO settings, P<0.01) associated with predicted miRNA target genes from S. pistillata.

miRNA	GO ID	Description	P value
Immunity
spi-miR-2022	GO:0044003	modification by symbiont of host morphology or physiology	0.0015
spi-miR-2022	GO:0019048	virus-host interaction	0.0086
spi-miR-temp-15	GO:0044130	negative regulation of growth of symbiont in host	0.00634
spi-miR-temp-15	GO:0032735	positive regulation of interleukin2 production	0.00119
spi-miR-temp-15	GO:0034134	toll-like receptor 2 signaling pathway	0.00188
spi-miR-temp-15	GO:0034142	toll-like receptor 4 signaling pathway	0.00626
spi-miR-temp-15	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	0.00314
spi-miR-temp-15	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	0.00314
spi-miR-temp-16	GO:0070498	interleukin-mediated signaling pathway	0.00019
spi-miR-temp-16	GO:0042102	positive regulation of T cell proliferation	0.00366
spi-miR-temp-20	GO:0032088	negative regulation of NF-kappaB transcription factor activity	0.0038
spi-miR-temp-26	GO:0051703	intraspecies interaction between organisms	0.0086
Biomineralisation
spi-miR-100	GO:0060348	bone development	0.00475
spi-miR-temp-7	GO:0030574	collagen catabolic process	0.00733
spi-miR-temp-8	GO:0001958	endochondral ossification	0.0069
spi-miR-temp-12	GO:0003417	growth plate cartilage development	0.00891
spi-miR-temp-13	GO:0070588	calcium ion transmembrane transport	0.0046
spi-miR-temp-15	GO:0060346	bone trabecula formation	0.00629
spi-miR-temp-15	GO:0003417	growth plate cartilage development	0.00119
spi-miR-temp-15	GO:0043931	ossification involved in bone maturation	6.50E-05
spi-miR-temp-16	GO:0045672	positive regulation of osteoclast differentiation	0.00776
spi-miR-temp-18	GO:0030509	BMP signaling pathway	0.0084
spi-miR-temp-18	GO:0030501	positive regulation of bone mineralization	0.0031
spi-miR-temp-19	GO:0015701	bicarbonate transport	0.00172
spi-miR-temp-23	GO:0061036	positive regulation of cartilage development	0.00066