Table 2. The demographic, clinical and pathological parameters of patients with anti-GBM disease.
| Patient | Gender | Age | pulmonary hemorrhage | SCr (µmol/L) | Anti-GBM antibodies in circulation (U/mL) | ANCA | Percentage of crescents in glomeruli | Routine direct immunofluorescence | ||||||
| IgG | IgA | IgM | C3c | C1q | FRA | Alb | ||||||||
| 1 | Male | 23 | + | 581 | 33 | − | 100% | 3+ (GCW) | − | − | − | − | − | − |
| 2 | Male | 23 | + | 224 | 13 | − | 90% | 3+ (GCW) | − | − | 3+ (GCW) | − | − | − |
| 3 | Male | 20 | + | 551 | 21 | − | 100% | 3+ (GCW) | − | − | 3+ (GCW) | − | − | − |
| 4 | Male | 59 | − | 427 | 13 | − | 82% | + (GCW) | − | − | 2+ (Ms) | − | − | − |
| 5 | Male | 22 | − | 269 | 96 | − | 84% | − | − | − | − | − | − | − |
| 6 | Male | 66 | − | 796 | 116 | + | 100% | 2+ (GCW) | − | − | − | − | − | − |
| 7 | Male | 62 | + | 955 | 176 | + | 100% | 3+ (GCW) | − | + (Ms) | 3+ (GCW) | + (GCW) | 3+ (GCW) | − |
| 8 | Female | 30 | − | 682 | 60 | − | 100% | 2+ (GCW) | − | + (Ms) | 2+ (Ms) | − | + (Ms) | − |
| 9 | Female | 21 | + | 614 | 113 | − | 100% | 3+ (GCW) | − | − | − | − | − | − |
| 10 | Female | 21 | + | 475 | 60 | − | 91% | − | − | − | − | − | + (Ms) | − |
SCr: serum creatinine, ANCA: anti-neutrophil cystoplasmic antibodies, FRA: fibrinogen related antigens, Alb: albumin, GCW: glomerular capillary wall, Ms: mesangium.
This study included two patients with negative staining for linear IgG, possibly because of the severe destruction of glomerular capillary walls. The diagnosis was confirmed by the detection of anti-GBM IgG in serum and linear IgG staining on paraffin tissue by immunofluorescence.