Table 3. Frequencies of genotypes and alleles of microRNA (miR)-146a and Ets-1 polymorphisms in pediatric uveitis patients and controls.
SNP | Genotyp Allele | Pediatric uveitis (n = 520) | Controls (n = 1204) | χ2 | p value | pc value | OR (95% CI) |
rs2910164 | GG | 113(0.217) | 163(0.135) | 18.127 | 2.07×10−5 | 3.11×10−4 | 1.773 (1.359–2.313) |
GC | 248(0.477) | 553(0.459) | 0.453 | 0.501 | NS | 1.073(0.873–1.319) | |
CC | 159(0.306) | 488(0.405) | 15.350 | 8.93×10−5 | 0.001 | 0.646(0.519–0.805) | |
G | 474(0.456) | 879(0.365) | 25.080 | 5.50×10−7 | 2.75×10−6 | 1.457(1.257–1.688) | |
C | 566(0.544) | 1529(0.635) | 25.080 | 5.50×10−7 | 2.75×10−6 | 0.686(0.592–0.796) | |
rs57095329 | AA | 317(0.609) | 801(0.665) | 4.937 | 0.026 | NS | 0.786(0.635–0.972) |
AG | 184(0.354) | 372(0.309) | 3.347 | 0.067 | NS | 1.225(0.985–1.522) | |
GG | 19(0.037) | 31(0.026) | 1.502 | 0.220 | NS | 1.435(0.803–2.564) | |
A | 818(0.787) | 1974(0.820) | 5.206 | 0.023 | NS | 0.810(0.676–0.971) | |
G | 222(0.213) | 434(0.180) | 5.206 | 0.023 | NS | 1.234 (1.030–1.479) | |
rs6864584 | CC | 2(0.004) | 5(0.004) | 0.008 | 0.927 | NS | 0.926(0.179–4.788) |
CT | 39(0.075) | 112(0.093) | 1.476 | 0.224 | NS | 0.791(0.541–1.156) | |
TT | 479(0.921) | 1087(0.903) | 1.466 | 0.226 | NS | 1.257(0.867–1.823) | |
C | 43 (0.041) | 122(0.051) | 1.384 | 0.239 | NS | 0.808(0.566–1.153) | |
T | 997(0.959) | 2286(0.949) | 1.384 | 0.239 | NS | 1.237(0.867–1.766) | |
rs1128334 | AA | 64(0.123) | 145(0.120) | 0.024 | 0.877 | NS | 1.025(0.749–1.403) |
AG | 253(0.487) | 544(0.452) | 1.760 | 0.185 | NS | 1.150(0.936–1.413) | |
GG | 203(0.390) | 515(0.428) | 2.085 | 0.149 | NS | 0.857(0.694–1.057) | |
A | 381(0.366) | 834(0.346) | 1.273 | 0.259 | NS | 1.091(0.938–1.270) | |
G | 659(0.634) | 1574(0.654) | 1.273 | 0.259 | NS | 0.916(0.788–1.066) | |
rs10893872 | CC | 209(0.402) | 359(0.298) | 17.695 | 2.59×10−5 | 3.89×10−4 | 1.582(1.277–1.960) |
CT | 218(0.419) | 620(0.515) | 13.320 | 2.63×10−4 | 0.004 | 0.680(0.552–0.837) | |
TT | 93(0.179) | 225(0.187) | 0.156 | 0.693 | NS | 0.948(0.726–1.238) | |
C | 636(0.612) | 1338(0.556) | 9.270 | 0.002 | 0.01 | 1.259(1.085–1.460) | |
T | 404(0.388) | 1070(0.444) | 9.270 | 0.002 | 0.01 | 0.794(0.685–0.921) |
pc, Bonferroni corrected p value; OR, odds ratio; NS, not significant; SNP, single nucleotide polymorphism.