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. 2014 Mar 21;9(3):e92309. doi: 10.1371/journal.pone.0092309

Figure 2. AβOs colocalize with the EphA4 receptor and induce changes in its subcellular localization.

Figure 2

(A) Cultured hippocampal neurons (21 DIV) were treated with 5 μM AβOs-FITC (green) for 0.5–1 hours and immunolabeled for EphA4 (red). Scale bars, 10 μm in the left panel and 5 μm in the right panels. (B) Hippocampal neurons (21 DIV) were treated with 3 μM AβOs or 9.5 μg/ml ephrin A3 Fc as a soluble EphA4 ligand for 1 hour or left untreated as a control. The neurons were then immunolabeled with an EphA4 antibody (green; B) or double-labeled with an EphA4 antibody and phalloidin-TRITC (red; C).