Figure 5. Cavin-1 deficient mice exhibit reduced vasomotion.

Panel A) shows original traces from two wild type (WT; black) and two knock out (KO; grey) arteries, mounted in a wire-myograph, after prolonged (1 h) incubation with cirazoline (0.1 μM). Note the absence of rhythmic force oscillations (vasomotion) in KO. Panel B) shows the fraction of vessels exhibiting vasomotion in WT and KO in the presence and absence of the gap junction blocker 18-α-glycyrrhetinic acid (18-α-GA). Panel C) shows expression of connexin 40 and 43 in the aorta and D) shows that 18-α-GA does not reduce the difference between WT and KO in α₁-adrenergic contraction.