Figure 7. Reduced myogenic tone in cavin-1^−/− mice.

Small mesenteric arteries were mounted in pressure myographs and their diameters at different pressures were recorded. A) Shows myogenic tone, calculated as described in Material and Methods, in control conditions. B) Shows myogenic tone in the presence of L-NAME (100 μM). Endothelium-dependent dilatation with acetylcholine is shown in (C) and phosphorylation of e-NOS is shown by western blotting in (D) in wild type (WT) and knock-out (KO) mice.