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. 2014 Mar 21;9(3):e92374. doi: 10.1371/journal.pone.0092374

Figure 5. Effect of i.t. Dex, Ropi, or their combination on CFA-induced neuronal activation.

Figure 5

s.c. CFA-induced thermal hyperalgesia was accompanied with the increase in the number of Fos-ir neurons to the peak at 2 h after injection, and gradually reduced but sustained to day 7 in the ipsilateral SDH (A1∼A4). Both i.t. individual and concomitant medications significantly inhibited neuronal activation indicated by less number of Fos-ir neurons in the ipsilateral SDH at 2 h after s.c. CFA injection (B∼E). Number of Fos-ir neurons was presented in F at 2 h, 1, 3 and 7 d after s.c. CFA injection, respectively. * p<0.05, ** p<0.01, *** p<0.001, compared with Saline-Veh group; ## p<0.01, ### p<0.001, compared with CFA-Dex&Ropi group. Scalebars = 10 μm in A4’, 50 μm in A1∼A4 and B∼E.