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. 2014 Mar 21;9(3):e92495. doi: 10.1371/journal.pone.0092495

Figure 3. Anti-ΔC NS1 and anti-DJ NS1 Abs reduce DENV-induced prolonged bleeding time in mice.

Figure 3

Control IgG, anti-DENV NS1, anti-ΔC NS1 or anti-DJ NS1 Abs (100 μg/mouse) were i.p. injected to C3H/HeN mice, and one day later 9×107 pfu/mouse of DENV were intradermally (i.d.) inoculated in mice. On days one and two post-infection, mice were i.p. injected with 100 μg Abs and the bleeding time was determined on day 3. (n = 5 for medium control and anti-DJ NS1 Abs groups, n = 6 for DENV infection alone, control IgG, anti-DENV NS1 and anti-ΔC NS1 Abs groups) * P<0.05.