. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: J Bone Miner Res. 2014 Apr;29(4):878–891. doi: 10.1002/jbmr.2105

Table 1.

Confocal and TEM imaging of the LCS transport features in the 8–9 month-old male control (CTL) and perlecan deficient (Hypo) mice

Measurements	Control Bone (CTL)		Perlecan Deficient Bone (Hypo)		p-value

	Mean (±SD)	Sample Size	Mean (±SD)	Sample size
Canalicular number density (#/μm²)	0.21 (±0.05)	30 lacunae	0.19 (±0.02)	30 lacunae	<0.05
Canalicular wall cross-sectional area (μm²)	0.081 (±0.001)	506 canaliculi	0.066 (±0.007)	475 canaliculi	<0.0001
Cell process cross-sectional area (μm²)	0.017 (±0.002)	506 canaliculi	0.014 (±0.002)	475 canaliculi	0.0002
Canalicular fluid annular area (μm²)	0.065 (±0.034)	506 canaliculi	0.053 (±0.026)	475 canaliculi	<0.0001
Lacunar fluid gap^* (μm)	0.47 (±0.27)	12 lacunae	0.38 (±0.17)	16 lacunae	0.32

Note: As there was no significant difference between the two groups, data were pooled, yielding a median value of 0.36 μm, which was used for the three-compartment modeling. Student’s t-tests were performed for comparisons.