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Summary of the changes in sphingolipid metabolic enzyme described in colon cancer, along with an overview of the major roles in cell homeostasis. Figure based on figure 9 in Kono et. al. [65], with permission. SM: Sphingomyelin; alk-SMase: alkaline-Sphingomyelinase; nCDase: neutral Ceramidase; SPL: Sphingosine-1-P Lyase; S1P: Sphingosine-1-Phosphate; SPPase: Sphingosine-1-P Phosphatase; SK: Sphingosine Kinase; CerS: Ceramide Synthase and GCS: Glucosylceramide Synthase.
