Fig. 4.

mRNA expression of calcium handling genes normalized to 18s RNA expression from the smooth muscle layer of control rats and rats 2-wk postobstruction. While all nine targets showed decreased expression in nonhyperactive animals 2 wk postsurgery, four targets were expressed more in animals displaying hyperactivity. *P < 0.05. Two additional targets exhibited a trend for increased expression in this group (^a P = 0.067). All alpha values were determined via one-way ANOVA. Values are means ± SE; n, no. of rats. CPI-17, PKC-potentiated phosphatase inhibitor of 17 kDa; IP₃, inositol 1,4,5-trisphosphate; Rock, Rho kinase; RYR, ryanodine receptor; SERCA2, sarco(endo)plasmic reticulum Ca²⁺-ATPase 2.