Figure 6.

Structure of the human HSD11B2 gene showing positions of relevant transcription factor binding sites. Schematic representation of the human HSD11B2 gene (not to scale) showing positions of relevant transcription factor binding sites. The gene spans 6.4 kb. Exonic sequences are shown as boxes; white boxes encode the open reading frame, with a red box and a blue box indicating the 5′ leader and the 3′ untranslated sequence, respectively. An arrow indicates the position of the promoter, although it should be noted that transcription starts at a number of sites clustered around the site shown (see text for details). Sp1/Sp3 sites are shown as green ovals (these overlap with Egr1 sites), an NF1 site is shown as a pink hexagon, and an NF-κB binding site is shown as a purple diamond. The positions of 2 polymorphisms that reduce transcription factor binding and promoter activity (18) are indicated by asterisks. See text for details.